Target discovery through genomics
Proteomic applications for target discovery
Target validation using saran,high content and imaging techniques, and tool or reference compounds
Biomarkers in disease research to give an early indication of efficacy |
Compound library design and optimisation
High throughput screening in target assays vs. phenotypic assays on focused libraries
Fragment-based lead discovery Lead discovery for less-tractable targets Off-target effects |
In silico ADMET
High content and cell-based assay
Early biomarkers for predicting safety
Toxicogenomics Idiosyncratic toxicology
Clinically relevant animal models |
